From: Jocelyn Leu
Subject:[NMusers] Emax modeling question
Date: 11/18/2003 9:38 AM

Hi all,
I am trying to fit data to the general Emax model.  We have tried
2 subjects and the control stream works ($PRED).  However, when
we use the entire data set, there are error messages.  From what
we can see, NONMEM is having problems with the data file. I have
multiple values of "0" for concentration and different values for
effect.  Has anyone experienced this or have a solution?  I'd like
delete as little data as possible.



From: "Bhattaram, Atul"
Subject: RE: [NMusers] Emax modeling question
Date: 11/18/2003 10:14 AM

Hello Leu
When you say "0" do you mean concentrations below "LOQ" or pre-dose? How
different is the overall data from the 2 subjects? You dont have to delete
any data.

Venkatesh Atul Bhattaram