From Thu Sep 7 16:57:20 1995
Subject: NONMEM on Macintosh's

I am interested in communicating with anyone who has setup NONMEM and population pharmacokinetic analyses on a Macintosh-esp power PC's, operating system 7.5. Any information on older Mac's may also be useful.


Janice B. Schwartz, M.D.
Professor of Medicine
Chief, Clinical Pharmacology and Geriatrics
Northwestern University Medical School
Jennings 209, 303 East Superior Street
Chicago, Illinois 60611


From alison Fri Sep 8 10:12:42 1995

David Bourne tried "Mac Fortran II v3.1.2 - Absoft - On a Macintosh IIci" This is what he had to say at the time.

-- Alison Boeckmann
From Fri Mar 31 09:55:34 1995
Subject: Re: NONMEM on the PowerMac

Absoft has come up with another version of their FORTRAN compiler for the Macintosh. This is V 4.1. I have recompiled the NONMEM files and put together another version of the help folder for other Macintosh/NONMEM users. Again the results are good (I think). I was able to optimize some files I couldn't before and not optimize one or two that optimized with v4.0 of the compiler. Oh well. The test runs are a little faster. I used the sample runs presented in:

NONMEM User's Guide Part III (Nov 92) Page 3. Using the NONMEM20-25 files.

   X    Time (sec)   File Size for          Memory        
                        NONMEM      Allocation set by    
PRED        13           576K              1217K        
ADVAN2      20           576K              1217K        
ADVAN7      143          585K              1217K        
ADVAN6      216          585K       1217K:-)            

as benchmarks. The timings etc. are shown above for a PowerMac6100/60AV. Times are about half the 1992 benchmark values. I've put together a few files including the make files for the Absoft compiler for the PowerMac v4.1. These are available at:


David Bourne, Ph.D.
OU HSC College of Pharmacy
Oklahoma City, OK 73117
Voice: (405) 271-6481